Start a custom requestLABEL POSITION MATTERS
Put the label where the question is.
When the available labeled analogue does not match your analyte or tracing question, a custom labeling pattern may be the better starting point. Headgroup-labeled variants are a particular focus; other sites can be discussed.
Discuss this custom lipid ↗RESEARCH-SPECIFIC, BY DESIGN
Illustrative starting briefs. Each requires confirmation of the exact structure and feasibility.
A requested PC or PE structure with a defined headgroup labeling pattern, rather than a label in the fatty-acid chains.
A labeled counterpart of a hard-to-source lipid for evaluation in a targeted analytical method.
A lipid with a specified label location to investigate the part of the molecule relevant to a research pathway.
Specify the isotope, number of labels and their positions when known. Include the desired enrichment and whether a distribution of isotopologues is acceptable. A drawing marking the atoms is especially useful.
For a tracing project, explain which part of the molecule you intend to follow. For an internal standard, identify the target analyte, analytical platform and relevant ions. The labeling plan should support that use rather than simply create a heavier molecule.
Chemical purity and isotopic enrichment are separate specifications. Agree on the evidence required for each, the amount needed and the presentation. A custom compound still needs validation in the researcher’s own analytical method; its availability does not establish method performance.
BEFORE YOU START
No. Headgroup labeling is a focus, and other defined labeling positions can be discussed. Feasibility depends on the exact molecule, label pattern and available starting materials.
Suitability depends on the analyte and method. Specify the intended measurement and validation requirements when requesting the material.
A CONVERSATION WITH CHEMISTS
Our laboratory is not yet open, but we’re ready to discuss and plan your custom lipid project.